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Photo of Patrick Brophy

Patrick Brophy

Associate Professor,  Pediatrics

Contact Information

Research Lab
1257 CBRB
Iowa City, IA 52242

Clinical Office
4035 BT
Iowa City, IA 52242

Phone: +1 319 356 7249
Email: patrick-brophy@uiowa.edu
Web: Brophy Faculty Bio

Education

BSc, University of Regina
BA, University of Saskatchewan
MD, Medicine, University of Saskatchewa
Residency, Pediatrics, University of Manitoba
Fellowship, Pediatric Nephrology, University of Michigan Medical Center

Appointments

Primary: Pediatrics
Secondary: Surgery

Centers and Program Affiliations

Interdisciplinary Graduate Program in Informatics

Research Interests


MeSH Terms from Publications

Renal Replacement Therapy, Acute Kidney Injury, Infant, Humans, Renal Dialysis, Child, Infant, Newborn, Hemofiltration, Child, Preschool, PAX2 Transcription Factor, Male, Retrospective Studies, Adolescent, Registries, Multiple Organ Failure, Critical Illness, Female, Treatment Outcome, Kidney, Hemodialysis Solutions, Kidney Failure, Chronic, Kidney Function Tests, Membranes, Artificial, Intensive Care Units, Pediatric, Branchio-Oto-Renal Syndrome

Research Summary

  1. Basic Science interests: 1) The genetic and developmental biology aspects underlying kidney formation, 2) Congenital and Genetic urogenital abnormalities – more specifically Bilateral/Unilateral renal agenesis (Potter’s Syndrome) and congenital progressive hydronephrosis.
  2. Translational/Collaborative Interests: Transplantation and Renal biobanks, Membranoproliferative Glomerulonephritis (MPGN) and atypical Hemolytic Uremic Syndrome
  3. Clinical Interests: member of the Prospective Pediatric Continuous Renal Replacement Therapy Registry, NAPRTCS, Chronic Kidney Disease, Acute Dialysis Quality Initiative (ADQI) and Acute Kidney Injury Network (AKIN).


Recent Publications


Show publications
  1. Brophy, P. Value of biomarkers to assess renal function following pediatric heart transplantation. Pediatr Transplant 15(6):543-5, 2011. [PubMed]
  2. Dagle, J, Fisher, T, Haynes, S, Berends, S, Brophy, P, Morriss, F, Murray, J. Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit. J Pediatr 159(1):104-9, 2011. [PubMed]
  3. Shetty, R, Reed, A, Myers, D, Brophy, P, Stewart, Z. Successful Treatment of Rapidly Recurrent FSGS with Plasmapheresis and Rituximab. AMERICAN JOURNAL OF TRANSPLANTATION 11(null):71-71, JAN 2011.
  4. Nester, C, Stewart, Z, Myers, D, Jetton, J, Nair, R, Reed, A, Thomas, C, Smith, R, Brophy, P. Pre-emptive Eculizumab and Plasmapheresis for Renal Transplant in Atypical Hemolytic Uremic Syndrome. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 6(6):1488-1494, JUN 2011.
  5. Auron, A, Brophy, P. Pediatric renal supportive therapies: the changing face of pediatric renal replacement approaches. Curr Opin Pediatr 22(2):183-8, 2010. [PubMed]
  6. Sutherland, S, Zappitelli, M, Alexander, S, Chua, A, Brophy, P, Bunchman, T, Hackbarth, R, Somers, M, Baum, M, Symons, J, Flores, F, Benfield, M, Askenazi, D, Chand, D, Fortenberry, J, Mahan, J, McBryde, K, Blowey, D, Goldstein, S. Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis 55(2):316-25, 2010. [PubMed]
  7. Hanna, M, Segar, J, Teesch, L, Brophy, P. METABOLOMIC MARKERS OF NEPHROTOXICITY IN NEWBORN RATS. PEDIATRIC RESEARCH 68(4):363-363, OCT 2010.
  8. Gbadegesin, R, Zhao, S, Charpie, J, Brophy, P, Smoyer, W, Lin, J. Significance of hemolysis on extracorporeal life support after cardiac surgery in children. Pediatr Nephrol 24(3):589-95, 2009. [PubMed]
  9. Walters, S, Porter, C, Brophy, P. Dialysis and pediatric acute kidney injury: choice of renal support modality. Pediatr Nephrol 24(1):37-48, 2009. [PubMed]
  10. Pinsky, M R, Brophy, P, Padilla, J, Paganini, E, Pannu, N. Fluid and volume monitoring. Int J Artif Organs 31(2):111-26, 2008. [PubMed]