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Photo of Heather Bartlett

Heather Bartlett

Associate Professor,  Pediatrics

Contact Information

Phone: +1 319 356 2845
Email: heather-bartlett@uiowa.edu
Web:

Education

BS, Biochemistry, University of Arizona
MD, Medicine, University of Arizona
Residency, Pediatrics, University of Arizona
Post-Doc, Pediatrics, University of Arizona
Fellowship, Pediatric Cardiology, University of Iowa

Appointments

Primary: Pediatrics
Secondary: Biochemistry

Centers and Program Affiliations


Research Interests

biochemistry, cardiology, heart disease, pediatrics, heart development, cardiovascular disease, actin, actin regulatory factors, protein chemistry, protein structure, aortic aneurysm, thoracic/metabolism, developmental gene expression regulation, heart/anatomy &, histology, heart/physiology

MeSH Terms from Publications

Xenopus laevis, Heart Defects, Congenital, Hypoplastic Left Heart Syndrome, Vena Cava, Superior, Microscopy, Video, Cardiac Surgical Procedures, Myocardial Contraction, Homeodomain Proteins, Humans, Obstetric Surgical Procedures, Heart Bypass, Right, Atrial Septum, Actin Depolymerizing Factors, Heart, Cardiovascular Abnormalities, Aminobenzoic Acids, Atracurium, Pancuronium, Tricuspid Valve, Protein Structure, Tertiary, Neuromuscular Blocking Agents, Aortic Aneurysm, Thoracic, Transcription Factors, Animals, Heart Valve Prosthesis Implantation

Research Summary

My research focuses on the molecular origins of cardiovascular disease. Current studies concentrate on the biochemical effects of actin mutations that cause a range of cardiovascular diseases in children and adults, including Familial Thoracic Aortic Aneurysm and Dissection.



Recent Publications


Show publications
  1. Bergeron, S, Wedemeyer, E, Lee, R, Wen, K, McKane, M, Pierick, A, Berger, A, Rubenstein, P, Bartlett, H. Allele-specific effects of thoracic aortic aneurysm and dissection alpha-smooth muscle actin mutations on actin function. J Biol Chem 286(13):11356-69, 2011. [PubMed]
  2. Bartlett, H, Veenstra, G, Weeks, D. Examining the cardiac NK-2 genes in early heart development. Pediatr Cardiol 31(3):335-41, 2010. [PubMed]
  3. Bartlett, H, Escalera, R, Patel, S, Wedemeyer, E, Volk, K, Lohr, J, Reinking, B. Echocardiographic assessment of cardiac morphology and function in Xenopus. Comp Med 60(2):107-13, 2010. [PubMed]
  4. Divekar, A, Morriss, J, Reinking, B, Bartlett, H. Transcatheter diagnosis and intervention for iatrogenic right-to-left shunts decades after surgical repair of partial anomalous pulmonary veins and an atrial septal defect. Pediatr Cardiol 30(8):1150-3, 2009. [PubMed]
  5. Divekar A, Morriss J, Reinking BE, Bartlett HL.  Transcatheter diagnosis and intervention for iatrogenic right-to-left shunts decades after surgical repair of partial anomalous pulmonary veins and an atrial septal defect.  Pediatric Cardiology, (2009);30:1150-1153.
  6. Bartlett HL, Weeks DL.  Lessons from the lily pad: using xenopus to understand heart disease.  Drug Discovery Today: Disease Models, Autumn 2008;5(3):141-146.
  7. Bartlett, H, Sutherland, L, Kolker, S, Welp, C, Tajchman, U, Desmarais, V, Weeks, D. Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis. Dev Dyn 236(9):2475-84, 2007. [PubMed]
  8. Von Bergen, N, Burkhart, H, Latson, L, Emery, S, Younoszai, A, Bartlett, H. Complete cavopulmonary shunt completion after in utero balloon atrial septoplasty for hypoplastic left heart syndrome. J Thorac Cardiovasc Surg 134(5):1355-6, 2007. [PubMed]
  9. Patel, P, Bartlett, H, Scholz, T, Burzynski, J, Behrendt, D, Burkhart, H. Norwood modification in a patient with hypoplastic left heart and a right aortic arch. J Thorac Cardiovasc Surg 134(4):1065-6, 2007. [PubMed]
  10. Bartlett, H, Atkins, D, Burns, T, Engelkes, K, Powell, S, Hills, C, Moller, J. Early outcomes of tricuspid valve replacement in young children. Circulation 115(3):319-25, 2007. [PubMed]