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Charles Clark

Professor,  Orthopaedic Surgery

Contact Information

Phone: +1 319 356 2332
Email: charles-clark@uiowa.edu



Primary: Orthopaedic Surgery
Secondary: Biomedical Engineering

Centers and Program Affiliations

Research Interests

total knee, zirconium, polyethylene, rotating platform, high flexion, cervical spine, anterior cervical discectomy and fusion, dysphasia

MeSH Terms from Publications

Research Summary

Dr. Clark is currently involved in four clinical research projects. Three deal with total knee arthroplasty, and the fourth deals with the cervical spine.

The first project involves a randomized controlled study comparing the same style of implant but made of two different materials: zirconium, which is a ceramic, vs. cobalt chrome, which is a metal, for the femoral component of a total knee arthroplasty.

The second total knee study involves a randomized controlled study comparing two different types of polyethylene as the bearing surface in total knees. The first type of polyethylene is called GVF which is gamma vacuum foil which is the sterilization method for the polyethylene. The second type of polyethylene is what is known as a cross-linked polyethylene which increases the wear characteristics of the polyethylene.

The third study is also a randomized controlled study involving total knees, however, has the patient as their own control. That is, it involves patients undergoing bilateral total knee replacements. Both patients are receiving what is called a rotating platform total knee in which the bearing surface on the tibial side actually rotates as the knee moves throughout a range of motion mimicking the normal kinematics of the knee. The experimental design involves a standard rotating platform knee on one side and then the high flex version on the other side, and the primary outcome measures are looking at the functioning as well as motion achieved with this knee.

The fourth project involves an analysis of dysphasia, or difficulty swallowing, following anterior cervical discectomy and fusion. Many patients following surgery having clinical or subclinical difficulty with swallowing following such a procedure, and this study involves a very sophisticated methodology to evaluate the blood flow to the throat during surgery.

Recent Publications

Show publications
  1. Asphalt fume dermal carcinogenicity potential: I. dermal carcinogenicity evaluation of asphalt (bitumen) fume condensates. Regul Toxicol Pharmacol 61(1):9-16, 2011. [PubMed]
  2. Asphalt fume dermal carcinogenicity potential: II. Initiation-promotion assay of Type III built-up roofing asphalt. Regul Toxicol Pharmacol 61(1):17-22, 2011. [PubMed]
  3. Chronic carcinogenicity study of gasoline vapor condensate (GVC) and GVC containing methyl tertiary-butyl ether in F344 rats. J Toxicol Environ Health A 74(10):638-57, 2011. [PubMed]
  4. Disorder specificity despite comorbidity: resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder. Biol Psychol 85(2):350-4, 2010. [PubMed]
  5. Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. J Virol 84(20):10671-80, 2010. [PubMed]
  6. Treatment approaches to prosthetic joint infections: results of an Emerging Infections Network survey. Diagn Microbiol Infect Dis 66(1):16-23, 2010. [PubMed]
  7. Multifactorial dysphagia: diffuse idiopathic skeletal hyperostosis and eosinophilic esophagitis. Laryngoscope 120(1):23-5, 2010. [PubMed]
  8. Primary hip and knee replacement: "are we all operating on the same patients, even at the same institution?". Iowa Orthop J 30:109-14, 2010. [PubMed]
  9. Multicenter collaboration in observational research: improving generalizability and efficiency. J Bone Joint Surg Am 91 Suppl 3:80-6, 2009. [PubMed]
  10. Perioperative blood management in total hip arthroplasty. Instr Course Lect 58:167-72, 2009. [PubMed]