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Photo of John Dagle

John Dagle

Professor,  Pediatrics

Contact Information

Phone: +1 319 353 7009
Email: john-dagle@uiowa.edu
Web:

Education

BS, Chemistry, Creighton University
MD, University of Iowa Carver College of Medicine
PhD, Biochemistry, University of Iowa
Residency, Pediatrics, University of Iowa Hospitals and Clinics
Fellowship, Neonatology, University of Iowa Hospitals and Clinics

Appointments

Primary: Pediatrics
Secondary: Biochemistry

Centers and Program Affiliations


Research Interests

gene expression, hypertension, neonatology, pediatrics, pulmonary disease

MeSH Terms from Publications

Infant, Premature, Xenopus laevis, Oligonucleotides, Antisense, Infant, Newborn, Polymorphism, Single Nucleotide, Gestational Age, Base Sequence, RNA, Messenger, Embryo, Nonmammalian, Genetic Predisposition to Disease, Animals, DNA, Ribonuclease H, Ethylenediamines, Female, Gastrula, Humans, Oligodeoxyribonucleotides, Antisense, Oocytes, Molecular Sequence Data, Phosphoric Acids, Gene Expression Regulation, Developmental, Xenopus Proteins, Oligodeoxyribonucleotides, Male

Research Summary

My clinical interests include pulmonary hypertension, prematurity, and the prevention and management of chronic lung disease. My research interests include the genetic basis of preterm delivery and the use of chemically modified oligonucleotides to alter gene expression.

Recent Publications


Show publications
  1. Applying deep DNA sequencing to common, complex pediatric traits. Pediatrics 130(6):e1677-8, 2012. [PubMed]
  2. Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates. J Perinatol 32(5):349-55, 2012. [PubMed]
  3. Improving survival of extremely preterm infants born between 22 and 25 weeks of gestation. Obstet Gynecol 119(4):795-800, 2012. [PubMed]
  4. Genetics of patent ductus arteriosus susceptibility and treatment. Semin Perinatol 36(2):98-104, 2012. [PubMed]
  5. Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn. Pediatr Res 71(2):162-7, 2012. [PubMed]
  6. Replication of a genome-wide association study of birth weight in preterm neonates. J Pediatr 160(1):19-24.e4, 2012. [PubMed]
  7. Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns. J Pediatr Endocrinol Metab 25(3-4):301-5, 2012. [PubMed]
  8. Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit. J Pediatr 159(1):104-9, 2011. [PubMed]
  9. Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates. Pediatr Res 70(1):90-5, 2011. [PubMed]
  10. Single-nucleotide polymorphisms in the KCNN3 gene associate with preterm birth. Reprod Sci 18(3):286-95, 2011. [PubMed]