Loki Home

Research Interests

Funding Opportunities

FAQ

UI Login Guest Login

Browse by Investigator Last Name



Browse Research


Photo of Charles Grose

Charles Grose

Professor,  Pediatrics

Contact Information

Phone: +1 319 356 2288
Email: charles-grose@uiowa.edu
Web:

Education

BA, Bachelor of Arts, Beloit College
MD, Medicine, University of Chicago School of Medicine
Internship, Internship, Albert Einstein College of Medicine
Residency, Pediatrics, Albert Einstein College of Medicine
Post-Doc, Immunology/Infectious Disease, Albert Einstein College of Medicine
Post-Doc, Immunology, University of California, San Francisco

Appointments

Primary: Pediatrics

Centers and Program Affiliations


Research Interests

pediatrics, molecular biology, immune system, varicella zoster virus, herpes virus

MeSH Terms from Publications

Herpesvirus 3, Human, Viral Envelope Proteins, Humans, Chickenpox, Viral Proteins, Virus Replication, Herpes Zoster, Giant Cells, Mice, SCID, Endocytosis, Genome, Viral, Autophagy, Animals, Membrane Glycoproteins, Sequence Alignment, Skin, Amino Acid Sequence, Herpesvirus 8, Human, Cell Line, Mutation, Molecular Sequence Data, Open Reading Frames, Membrane Fusion, Protein Kinases, Child

Research Summary

Research Interests: Varicella-zoster virus. VZV is the virus that causes chickenpox in children and shingles in the elderly. We study the components of the virus. We use a variety of molecular biology techniques. We also use the newest imaging techniques, to determine the sites on the virus that interact with the cell. Of recent interest, we have discovered the first mutant strain of varicella-zoster ever found anywhere in the world. Human herpes virus type 8. HHV-8 causes Kaposi sarcoma in AIDS patients. However, 3 to 5% of otherwise healthy people in the United States are infected with this virus. It is not known how this virus is transmitted from person to person. We are currently studying neonates in Iowa to determine if the virus is transmitted at time of delivery or shortly thereafter.



Recent Publications


Show publications
  1. COMMENTARY: Significantly Less Anti-gC Antibody Detectable in Sera Collected After Varicella Vaccination Than After the Disease Varicella. Pediatr Infect Dis J 31(11):1153-4, 2012. [PubMed]
  2. The attenuated genotype of varicella-zoster virus includes an ORF0 transitional stop codon mutation. J Virol 86(19):10695-703, 2012. [PubMed]
  3. Neurovirulence of varicella and the live attenuated varicella vaccine virus. Semin Pediatr Neurol 19(3):124-9, 2012. [PubMed]
  4. Acute retinal necrosis caused by herpes simplex virus type 2 in children: reactivation of an undiagnosed latent neonatal herpes infection. Semin Pediatr Neurol 19(3):115-8, 2012. [PubMed]
  5. Pangaea and the Out-of-Africa Model of Varicella-Zoster Virus Evolution and Phylogeography. J Virol 86(18):9558-65, 2012. [PubMed]
  6. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8(4):445-544, 2012. [PubMed]
  7. Autophagosome formation during varicella-zoster virus infection following endoplasmic reticulum stress and the unfolded protein response. J Virol 85(18):9414-24, 2011. [PubMed]
  8. Calculation of the anterograde velocity of varicella-zoster virions in a human sciatic nerve during shingles. J Infect Dis 203(3):324-6, 2011. [PubMed]
  9. Autophagy during common bacterial and viral infections of children. Pediatr Infect Dis J 29(11):1040-2, 2010. [PubMed]
  10. Stroke after varicella and zoster ophthalmicus: another indication for treatment and immunization. Pediatr Infect Dis J 29(9):868-9, 2010. [PubMed]