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Photo of Michael Knudson

Michael Knudson

Associate Professor,  Pathology

Contact Information

Phone: +1 319 335 8147
Email: c-knudson@uiowa.edu
Web: Research Laboratory

Education

BS, The University of Iowa
MD, The University of Iowa
PhD, The University of Iowa
Residency, Laboratory Medicine, Department of Pathology, Washington University Medical Center, St. Louis, MO

Appointments

Primary: Pathology
Secondary: Radiation Oncology

Centers and Program Affiliations

Interdisciplinary Graduate Program in Molecular and Cellular Biology

Research Interests

apoptosis, bax, oncogenesis, proliferation

MeSH Terms from Publications

bcl-2-Associated X Protein, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins, Animals, Apoptosis, Mice, Sarcoplasmic Reticulum, Cell Survival, Mice, Transgenic, Muscles, Ryanodine Receptor Calcium Release Channel, Cell Death, Receptors, Cholinergic, Ion Channels, Molecular Weight, Tumor Suppressor Protein p53, Mice, Knockout, Lymphoma, T-Cell, Caspases, Muscle Proteins, Calcium Channels, Chromosomal Instability, Calcium, Cells, Cultured, Rabbits

Research Summary

My research interests involve the role of Bcl-2 family of proteins in oncogenesis. Our recent studies have examined potential novel therapies for the treatment of lymphoma.  We have initiated studies of human specimens.  In an effort to facilitate more translational research, I became the Director of the Tissue Procurement Core in 2010.  During this time we have collaborated with a number of investigators in the consenting and collection of tissue specific specimens including Breast cancer, melanoma and sarcoma.  With this experience the TPC is well positioned to help with the collection, storage and distributions of neuroendocrine tumors.  We are anxious to help with the studies in any way we can.



Recent Publications


Show publications
  1. Wang, S, Martin, S, Harris, P, Knudson, C. Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma. PLoS One 6(5):e19786, 2011. [PubMed]
  2. Du J, Martin SM, Wang Y, Levine M, Wagner BA, Buettner GR, Taghiyev AF, Du C, Knudson CM, Cullen JJ.  Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer.  Clinical Cancer Research.  16(2):509-20, 2010.

  3. Knudson, C, Brown, N. Mitochondria potential, bax "activation," and programmed cell death. Methods Mol Biol 414:95-108, 2008. [PubMed]
  4. Cheng, N, van de Wetering, C, Knudson, C. p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma. PLoS One 3(4):e1911, 2008. [PubMed]
  5. van de Wetering, C, Coleman, M, Spitz, D, Smith, B, Knudson, C. Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma. Free Radic Biol Med 44(8):1677-86, 2008. [PubMed]
  6. Bell, A M, Nolen, J, Knudson, C M, Raife, T J. Severe citrate toxicity complicating volunteer apheresis platelet donation. J Clin Apher 22(1):15-6, 2007. [PubMed]
  7. Brown, N, Martin, S, Maurice, N, Kuwana, T, Knudson, C. Caspase inhibition blocks cell death and results in cell cycle arrest in cytokine-deprived hematopoietic cells. J Biol Chem 282(4):2144-55, 2007. [PubMed]
  8. van de Wetering, C, Horne, M, Knudson, C. Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma. Cancer Res 67(17):8081-8, 2007. [PubMed]
  9. Gould, T, Buss, R, Vinsant, S, Prevette, D, Sun, W, Knudson, C, Milligan, C, Oppenheim, R. Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci 26(34):8774-86, 2006. [PubMed]
  10. Hadzic, T, Li, L, Cheng, N, Walsh, S, Spitz, D, Knudson, C. The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion. J Immunol 175(12):7965-72, 2005. [PubMed]