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Photo of Manickam Muruganandham

Manickam Muruganandham

This person no longer has an active appointment with the University of Iowa.


BS, Physics, University of Madras, Madras India
MS, Medical Physics, College of Engineering / Adyar Cancer Institute, Anna University
MS, BioPhysics, National Institute of Mental Health and Neurosciences(NIMHANS), Bangalore, India
PhD, Physics, University of Delhi, Delhi, India

Research Interests

MeSH Terms from Publications

Research Summary

Magnetic Resonance (MR) Functional Tumor Imaging in Radiation Therapy (RT)

-Magnetic Resonance Spectroscopic Imaging (MRSI)
-Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI)
-MR Diffusion imaging
-Tumor Hypoxia
-MR imaging of tumor redox status.

 Image Guided Radiation Therapy (IGRT)
-MR functional tumor imaging guided radiation treatment planning
-Work flow integration of MR functional tumor imaging methods in RT


Imaging Response Assessment of Tumors to Treatment using MR
-Identification of non-invasive MR imaging biomarkers to predict tumor response to treatments

Recent Publications

Show publications
  1. Bayouth, J, Casavant, T, Graham, M, Sonka, M, Muruganandham, M, Buatti, J. Image-based biomarkers in clinical practice. Semin Radiat Oncol 21(2):157-66, 2011. [PubMed]
  2. Kim, Y, Muruganandham, M, Modrick, J, Bayouth, J. Evaluation of artifacts and distortions of titanium applicators on 3.0-Tesla MRI: feasibility of titanium applicators in MRI-guided brachytherapy for gynecological cancer. Int J Radiat Oncol Biol Phys 80(3):947-55, 2011. [PubMed]
  3. Kalderon, N, Muruganandham, M, Koutcher, J, Potuzak, M. Therapeutic strategy for acute spinal cord contusion injury: cell elimination combined with microsurgical intervention. PLoS One 2(6):e565, 2007. [PubMed]
  4. Muruganandham, M, Lupu, M, Dyke, J, Matei, C, Linn, M, Packman, K, Kolinsky, K, Higgins, B, Koutcher, J. Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast-enhanced MRI at 1.5 T. Mol Cancer Ther 5(8):1950-7, 2006. [PubMed]
  5. Muruganandham, M, Alfieri, A, Matei, C, Chen, Y, Sukenick, G, Schemainda, I, Hasmann, M, Saltz, L, Koutcher, J. Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy. Clin Cancer Res 11(9):3503-13, 2005. [PubMed]
  6. Zakian, K, Sircar, K, Hricak, H, Chen, H, Shukla-Dave, A, Eberhardt, S, Muruganandham, M, Ebora, L, Kattan, M, Reuter, V, Scardino, P, Koutcher, J. Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy. Radiology 234(3):804-14, 2005. [PubMed]
  7. Muruganandham, M, Koutcher, J, Pizzorno, G, He, Q. In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer. Magn Reson Med 52(4):902-6, 2004. [PubMed]
  8. Shukla-Dave, A, Hricak, H, Eberhardt, S, Olgac, S, Muruganandham, M, Scardino, P, Reuter, V, Koutcher, J, Zakian, K. Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings--initial observations. Radiology 231(3):717-24, 2004. [PubMed]
  9. Zakian, K, Eberhardt, S, Hricak, H, Shukla-Dave, A, Kleinman, S, Muruganandham, M, Sircar, K, Kattan, M, Reuter, V, Scardino, P, Koutcher, J. Transition zone prostate cancer: metabolic characteristics at 1H MR spectroscopic imaging--initial results. Radiology 229(1):241-7, 2003. [PubMed]