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Photo of Jeffrey Murray

Jeffrey Murray

Professor,  Pediatrics

Contact Information

Phone: +1 319 335 6897
Email: jeff-murray@uiowa.edu
Web:

Education

BS, Biology, Massachuetts Institute of Technology
MD, Medicine, Tufts University
Residency, Pediatrics, New England Medical Center
Fellowship, Medical Genetics, University of Washington

Appointments

Primary: Pediatrics
Secondary: Biological Sciences
Secondary: International Programs-Grants/Programs
Secondary: Pediatric Dentistry
Secondary: Administration
Secondary: Anatomy & Cell Biology
Secondary: Epidemiology
Secondary: Public Policy Center
Secondary: Nursing

Centers and Program Affiliations

Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Molecular and Cellular Biology

Research Interests

birth or congenital defect, Brazil, cataract, craniofacial disorder, detailed linkage map, eye disease, gene environment interaction, glaucoma, human genome, Human Genome Project, medical ethics, molecular genetic epidemiology, molecular genetics, non-syndromic cleft lip, non-syndromic cleft palate, pediatrics, Philippines, premature, prematurity, sequence-based polymorphism

MeSH Terms from Publications

Humans, Chromosome Mapping, Chromosomes, Human, Pair 4, Polymorphism, Genetic, Cleft Palate, Cleft Lip, Genetic Linkage, Polymorphism, Restriction Fragment Length, Genetic Markers, Base Sequence, Molecular Sequence Data, Animals, Female, Homeodomain Proteins, Male, Chromosomes, Human, Pair 1, Pedigree, Mice, Syndrome, DNA, Genes, Homeobox, Collagen, Deoxyribonucleases, Type II Site-Specific, Transcription Factors, Endothelium, Vascular

Research Summary

My research involves investigation of molecular genetic epidemiology of non-syndromic cleft lip and palate and the mutational basis for a variety of craniofacial disorders. Projects also involve studies of gene environment interactions, the ethics of the human genome project and training programs for secondary school science teachers. Several international collaborative efforts, are underway in the Philippines, Russia, and Brazil. We use molecular and mouse model systems to study facial development as well as inherited forms of cataracts and glaucoma. Mouse work involves gene knockouts and expression studies of several different homeobox genes.

Recent Publications


Show publications
  1. Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates. J Perinatol 32(5):349-55, 2012. [PubMed]
  2. Clinical findings in patients with GLI2 mutations--phenotypic variability. Clin Genet 81(1):70-5, 2012. [PubMed]
  3. Genome-wide association scan for childhood caries implicates novel genes. J Dent Res 90(12):1457-62, 2011. [PubMed]
  4. Genetic studies in the nigerian population implicate an MSX1 mutation in complex oral facial clefting disorders. Cleft Palate Craniofac J 48(6):646-53, 2011. [PubMed]
  5. Global oral health inequalities: challenges in the prevention and management of orofacial clefts and potential solutions. Adv Dent Res 23(2):247-58, 2011. [PubMed]
  6. Folic acid and orofacial clefts: a review of the evidence. Oral Dis 16(1):11-9, 2010. [PubMed]
  7. PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene 28(2):306-12, 2009. [PubMed]
  8. Identification of novel candidate genes associated with cleft lip and palate using array comparative genomic hybridisation. J Med Genet 45(2):81-6, 2008. [PubMed]
  9. Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. J Perinatol 27(11):672-80, 2007. [PubMed]
  10. Abnormal brain structure in adults with Van der Woude syndrome. Clin Genet 71(6):511-7, 2007. [PubMed]