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Photo of Jessica Moreland

Jessica Moreland

This person no longer has an active appointment with the University of Iowa.

Education

BS, Zoology, Duke University, Durham, North Carolina
MD, Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
Residency, Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
Fellowship, Pediatric Critical Care, Vanderbilt University Medical Center, Nashville, Tennesee

Research Interests

pediatrics, respiratory system

MeSH Terms from Publications

Neutrophils, Chloride Channels, Cell Movement, NADPH Oxidase, Neutrophil Activation, Vascular Endothelial Growth Factors, Endothelial Growth Factors, Animals, Streptococcus pneumoniae, Lung, Lymphokines, Endothelial Cells, Humans, Tularemia, Vascular Endothelial Growth Factor A, Antigens, CD11b, Hyperoxia, Staphylococcus aureus, Virulence, Francisella tularensis, Antigens, CD18, Mice, Chlorides, Lipopolysaccharides, Endothelium, Vascular

Research Summary

Clinical Interests: Pediatric respiratory failure, alternative modes of ventilation and ECMO. Research Interests: Pulmonary neutrophil recruitment in endotoxin induced airway disease; role of endothelial and leukocyte adhesion molecules in pulmonary neutrophil recruitment.

Recent Publications


Show publications
  1. Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk APD, Moreland JG. Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species. Journal of Biological Chemistry. In Press. 2012 Jan 10.  
  2. Volk, A, Barber, B, Goss, K, Ruff, J, Heise, C, Hook, J, Moreland, J. Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-? is partially oxygen dependent. J Innate Immun 3(3):298-314, 2011. [PubMed]
  3. Matsuda, J, Filali, M, Moreland, J, Miller, F, Lamb, F. Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. J Biol Chem 285(30):22864-73, 2010. [PubMed]
  4. McCaffrey, R, Schwartz, J, Lindemann, S, Moreland, J, Buchan, B, Jones, B, Allen, L. Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. J Leukoc Biol 88(4):791-805, 2010. [PubMed]
  5. Moreland, J, Hook, J, Bailey, G, Ulland, T, Nauseef, W. Francisella tularensis directly interacts with the endothelium and recruits neutrophils with a blunted inflammatory phenotype. Am J Physiol Lung Cell Mol Physiol 296(6):L1076-84, 2009. [PubMed]
  6. Drake, J, Strohbehn, G, Bair, T, Moreland, J, Henry, M. ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells. Mol Biol Cell 20(8):2207-17, 2009. [PubMed]
  7. Lamb FS, Moreland JG, Miller FJ.  Electrophysiology of reactive oxygen production in signaling endosomes.  Antioxidants and Redox Signaling, 2009; 11(6): 1335-47.
  8. Volk, A, Heise, C, Hougen, J, Artman, C, Volk, K, Wessels, D, Soll, D, Nauseef, W, Lamb, F, Moreland, J. ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change. J Biol Chem 283(49):34315-26, 2008. [PubMed]
  9. Matsuda, J, Filali, M, Volk, K, Collins, M, Moreland, J, Lamb, F. Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent. Am J Physiol Cell Physiol 294(1):C251-62, 2008. [PubMed]
  10. Rabi, F, Morgan, D, Brophy, P, Moreland, J, Tobias, J. COMBINED FUROSEMIDE AND CHLOROTHIAZIDE DRIP: AN OPTION FOR DIURESIS.. CRITICAL CARE MEDICINE 36(12):A154-A154, DEC 2008.