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Photo of Robert Roghair

Robert Roghair

Associate Professor,  Pediatrics

Contact Information

Phone: +1 319 335 9895
Email: robert-roghair@uiowa.edu
Web:

Education

BS, Pharmacy, University of Iowa College of Pharmacy
MD, Medicine, University of Iowa Carver College of Medicine
Residency, Pediatrics, University of Iowa Children's Hospital
Fellowship, Neonatology, University of Iowa Children's Hospital

Appointments

Primary: Pediatrics

Centers and Program Affiliations


Research Interests

cardiovascular disease, neonatal disorder, nephrology, pediatrics, pharmacology

MeSH Terms from Publications

Sheep, Pregnancy, Prenatal Exposure Delayed Effects, Glucocorticoids, Dexamethasone, Coronary Vessels, Animals, Animals, Newborn, Female, Fetal Development, Blood Pressure, Vasoconstriction, Angiotensin II, Hypertension, Mesenteric Arteries, Gestational Age, Glucose Tolerance Test, Insulin Resistance, 11-beta-Hydroxysteroid Dehydrogenases, Mice, Carbenoxolone, Mice, Inbred C57BL, Disease Susceptibility, Superoxides, Diet, Protein-Restricted

Research Summary

I am interested in developmental origins of adult sympathetic activation and cardiovascular disease, including the effects of neonatal leptin deficiency and neonatal antidepressant exposure.

Recent Publications


Show publications
  1. Sex-specific programming of hypertension in offspring of late-gestation diabetic rats. Pediatr Res 72(4):352-61, 2012. [PubMed]
  2. Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity. Am J Physiol Regul Integr Comp Physiol 303(5):R513-9, 2012. [PubMed]
  3. Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice. J Nutr Metab 2012:431574, 2012. [PubMed]
  4. Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice. Clin Sci (Lond) 121(10):427-36, 2011. [PubMed]
  5. Neonatal leptin administration alters regional brain volumes and blocks neonatal growth restriction-induced behavioral and cardiovascular dysfunction in male mice. Pediatr Res 69(5 Pt 1):406-12, 2011. [PubMed]
  6. Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep. Am J Physiol Regul Integr Comp Physiol 298(6):R1607-14, 2010. [PubMed]
  7. Neonatal macrosomia is an independent risk factor for adult metabolic syndrome. Neonatology 98(3):238-44, 2010. [PubMed]
  8. Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats. Clin Sci (Lond) 117(3):129-38, 2009. [PubMed]
  9. Neonatal catch up growth increases diabetes susceptibility but improves behavioral and cardiovascular outcomes of low birth weight male mice. Pediatr Res 66(1):53-8, 2009. [PubMed]
  10. Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria. Clin Sci (Lond) 116(8):659-68, 2009. [PubMed]