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Photo of Jeffrey Segar

Jeffrey Segar

Professor,  Pediatrics

Contact Information

Professor and Director
8803 JPP
Iowa City, IA 52242

Phone: +1 319 356 7244
Email: jeffrey-segar@uiowa.edu
Web:

Education

BS, Zoology, University of Wisconsin, Madison
MD, Medicine, University of Wisconsin, Madison
Residency, Pediatrics, University of Iowa
Fellowship, Neonatology, University of Iowa

Appointments

Primary: Pediatrics

Centers and Program Affiliations


Research Interests

Angiotensin II, baroreflex, cardiovascular physiology, fetus, nervous system, pediatrics, sympathetic nervous system

MeSH Terms from Publications

Sheep, Animals, Animals, Newborn, Fetus, Pregnancy, Sympathetic Nervous System, Angiotensin II, Blood Pressure, Kidney, Baroreflex, Heart Rate, Gestational Age, Female, Heart Rate, Fetal, Prenatal Exposure Delayed Effects, Glucocorticoids, Myocardium, Arteries, Receptors, Angiotensin, Heart Ventricles, Embryonic and Fetal Development, Gene Expression Regulation, Developmental, Heart, Dexamethasone, Renin-Angiotensin System

Research Summary

My primary interest is in developmental physiology, and in particular fetal cardiovascular physiology My research is primarily related to neurohumoral control of circulatory function, cardiac adaptiation to increased load, and investigations of the "fetal origins of adult disease" hypothesis.

Recent Publications


Show publications
  1. Sex-specific programming of hypertension in offspring of late-gestation diabetic rats. Pediatr Res 72(4):352-61, 2012. [PubMed]
  2. Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity. Am J Physiol Regul Integr Comp Physiol 303(5):R513-9, 2012. [PubMed]
  3. Neonatal diuretic therapy: furosemide, thiazides, and spironolactone. Clin Perinatol 39(1):209-20, 2012. [PubMed]
  4. Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene. J Nutr Metab 2012:930364, 2012. [PubMed]
  5. Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice. Clin Sci (Lond) 121(10):427-36, 2011. [PubMed]
  6. Transfusion effects on cardiomyocyte growth and proliferation in fetal sheep after chronic anemia. Pediatr Res 69(6):485-90, 2011. [PubMed]
  7. The effect of adrenalectomy on the cardiac response to subacute fetal anemia. Can J Physiol Pharmacol 89(2):79-88, 2011. [PubMed]
  8. Programming of adult cardiovascular disease following exposure to late-gestation hyperglycemia. Neonatology 100(2):198-205, 2011. [PubMed]
  9. Effect of insulin and dexamethasone on fetal assimilation of maternal glucose. Endocrinology 152(1):255-62, 2011. [PubMed]
  10. Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep. Am J Physiol Regul Integr Comp Physiol 298(6):R1607-14, 2010. [PubMed]