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Aliye Uc

Associate Professor,  Pediatrics

Contact Information

Associate Professor of Pediatrics and Radiation Oncology
2865 JPP
Iowa City, IA 52242

Phone: +1 319 384 6032
Email: aliye-uc@uiowa.edu
Web:

Education

MD, Medicine, Istanbul University School of Medicine
Residency, Pediatrics, Hacettepe University Children's Hospital
Fellowship, Pediatric Gastroenterology, University of Iowa Hospitals and Clinics

Appointments

Primary: Pediatrics
Secondary: Radiation Oncology

Centers and Program Affiliations


Research Interests

gastroenterology, liver disorder, oxidative stress, pediatrics

MeSH Terms from Publications

Caco-2 Cells, Hemin, Heme Oxygenase (Decyclizing), Humans, Esophagogastric Junction, Opossums, Protoporphyrins, Muscle Relaxation, Animals, Newborn, Abdominal Pain, Vomiting, Female, Manometry, Child, Duodenum, Cystic Fibrosis Transmembrane Conductance Regulator, Myoelectric Complex, Migrating, Animals, Gastrointestinal Diseases, Male, Dyspepsia, Heme Oxygenase-1, Swine, Pyloric Antrum, Metalloporphyrins

Research Summary

My interests include all gastrointestinal and liver disorders of childhood, with special interest in gastrointestinal motility disorders and functional gastrointestinal disorders, regulation of heme iron uptake and transport in the intestines, and role of oxidative stress in intestinal electrolyte secretion.

Recent Publications


Show publications
  1. Abu-El-Haija, M, Ramachandran, S, Meyerholz, DK, Abu-El-Haija, M, Griffin, M, Giriyappa, R, Welsh, MJ, McCray, P, Uc, A. PANCREATIC DAMAGE IN A CYSTIC FIBROSIS PIG MODEL INVOLVES THE ACTIVATION OF PROINFLAMMATORY PATHWAYS. PEDIATRIC PULMONOLOGY null(null):394-395, 2011.
  2. Meyerholz, DK, Olivier, AK, Hochstedler, C, Naumann, P, Stoltz, DA, McCray, PB, Welsh, MJ, Uc, A. BETA CELL DISTRIBUTION, BUT NOT BETA CELL DENSITY, IS ALTERED IN THE NEONATAL CF PIG PANCREAS. PEDIATRIC PULMONOLOGY null(null):403-403, 2011.
  3. Meyerholz, DK, Stoltz, DA, Uc, A, McCray, PB, Welsh, MJ. MORPHOMETRIC ANALYSIS OF EXOCRINE PIG PANCREAS SUGGESTS A SEQUENTIAL PATHOGENESIS FOR FETAL CF PANCREAS DISEASE. PEDIATRIC PULMONOLOGY null(null):279-279, 2011.
  4. Stoltz, DA, Meyerholz, DK, Pezzulo, AA, Rokhlina, T, Chen, J, Ostedgaard, LS, Karp, PH, Ernst, SE, Ludwig, PS, Rector, MV, Reznikov, L, Taft, PJ, Wohlford-Lenane, C, Dohrn, C, Hornick, EE, Gansemer, ND, Hoegger, M, Samuel, MS, Brogden, KA, Uc, A, McCray, PB, Zabner, J, Prather, RS, Welsh, MJ. INTESTINAL EXPRESSION OF CFTR ALLEVIATES THE MECONIUM ILEUS PHENOTYPE IN CYSTIC FIBROSIS PIGS. PEDIATRIC PULMONOLOGY null(null):276-276, 2011.
  5. Ostedgaard, LS, Meyerholz, DK, Chen, JH, Pezzulo, AA, Karp, PH, Rokhlina, T, Ernst, SE, Hanfland, RA, Reznikov, LR, Ludwig, PS, Rogan, MP, Davis, GJ, Dohrn, CL, Wohlford-Lenane, C, Taft, PJ, Rector, MV, Hornick, E, Nassar, BS, Samuel, M, Zhang, YP, Richter, SS, Uc, A, Shilyansky, J, Prather, RS, McCray, PB, Zabner, J, Welsh, MJ, Stoltz, DA. The Delta F508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs. SCIENCE TRANSLATIONAL MEDICINE 3(74):-, MAR 16 2011.
  6. Uc, A, Stoltz, DA, Ludwig, PS, Pezzulo, A, Griffin, M, Abu-El-Haija, M, Abu-El-Haija, M, Meyerholz, D, Taft, PJ, Welsh, MJ. Pancreatic and Biliary Secretion Differ in Cystic Fibrosis and Wild-Type Pigs. GASTROENTEROLOGY 140(5):S856-S856, MAY 2011.
  7. Husain, SZ, Bai, HX, Barth, BA, Wilschanski, M, Alhosh, R, Durie, PR, Lowe, M, Morinville, VD, Uc, A. Practice Patterns of Pediatric Gastroenterologists Caring for Children With Acute and Chronic Pancreatitis. GASTROENTEROLOGY 140(5):S685-S685, MAY 2011.
  8. Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov L, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Taft PJ, Rector MV, Hornick E, Nassar P, Samuel M, Richter SS, Uc A, Shilyansky J, Prather RS, McCray, Jr., PB, Zabner J, Welsh MJ, Stoltz DA. Low Levels of cftr Activity in CFTRDF508/DF508 Pigs Do Not Prevent the Gastrointestinal and Lung Disease of Cystic Fibrosis. Science Translational Medicine, 3:74ra24; 2011.

  9. Uc, A. Chronic Pancreatitis in Children: Current Knowledge in Diagnosis and Treatment. Journal of Pediatric Sciences 2011:3(4); e98.

  10. Uc A, Zhu X, Wagner BA, Buettner GR, Berg DJ. Heme Oxygenase-1 is Protective against Non-Steroidal Anti-inflammatory Drug-Induced Gastric Ulcers. Journal of Pediatric Gastroenterology and Nutrition, 2011 Aug 25. [Epub ahead of print]. PMID: 21873894.