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Photo of Alexandra Volk

Alexandra Paige Davis Volk

Assistant Professor,  Pediatrics

Contact Information

PICU office
7770-C JPP
Iowa City, IA 52242

Lab Office
1269 CBRB
Iowa City, IA 52242

Phone: +1 319 356 4190
Email: paige-volk@uiowa.edu
Web:

Education

BA, Biochemistry and Chemistry, Cornell College
MD, Medicine, University of Iowa
Residency, Pediatrics, University of Iowa
Fellowship, Pediatric Critical Care, University of Iowa

Appointments

Primary: Pediatrics

Centers and Program Affiliations


Research Interests


MeSH Terms from Publications

Neutrophils, Chloride Channels, Neutrophil Activation, Cell Movement, NADPH Oxidase, p38 Mitogen-Activated Protein Kinases, Staphylococcus aureus, Niflumic Acid, Zinc Compounds, Secretory Vesicles, Antigens, CD11b, Oxygen, Large-Conductance Calcium-Activated Potassium Channels, Enzyme Activation, Cell Line, Tumor, Nitrobenzoates, Animals, Respiratory Burst, Mice, N-Formylmethionine Leucyl-Phenylalanine, Neisseria meningitidis, Blood Bactericidal Activity, Cell Shape, Anaerobiosis, Humans

Research Summary



Recent Publications


Show publications
  1. Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk APD, Moreland JG. Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species. Journal of Biological Chemistry. 2012 Jan 10.  In Press.
  2. Volk, A, Barber, B, Goss, K, Ruff, J, Heise, C, Hook, J, Moreland, J. Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-? is partially oxygen dependent. J Innate Immun 3(3):298-314, 2011. [PubMed]
  3. Volk, A, Heise, C, Hougen, J, Artman, C, Volk, K, Wessels, D, Soll, D, Nauseef, W, Lamb, F, Moreland, J. ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change. J Biol Chem 283(49):34315-26, 2008. [PubMed]
  4. Moreland, J, Davis, A, Matsuda, J, Hook, J, Bailey, G, Nauseef, W, Lamb, F. Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3. J Biol Chem 282(47):33958-67, 2007. [PubMed]
  5. Femling, J, Cherny, V, Morgan, D, Rada, B, Davis, A, Czirják, G, Enyedi, P, England, S, Moreland, J, Ligeti, E, Nauseef, W, DeCoursey, T. The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels. J Gen Physiol 127(6):659-72, 2006. [PubMed]
  6. Moreland, J, Davis, A, Bailey, G, Nauseef, W, Lamb, F. Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration. J Biol Chem 281(18):12277-88, 2006. [PubMed]