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Roger Williamson

This person no longer has an active appointment with the University of Iowa.


BS, Colorado State University, Fort Collinds, CO
MS, Baylor College of Medicine, Houston, TX
MD, Medicine, Baylor College of Medicine, Houston, TX
Internship, Pediatrics, Baylor-Affiliated Program, Houston, TX
Residency, Obstetrics and Gynecology, University of New Mexico School of Medicine
Fellowship, Medical Genetics, University of Washington School of Medicine

Research Interests

MeSH Terms from Publications

Research Summary

Dr. Williamson's laboratory is currently engaged in research within the context of the Wellstone Muscular Dystrophy Cooperative Research Center. His participation in this grant is an extension of previous collaborative research relating to mouse muscular dystrophy mutants produced by gene targeting in murine embryonic stem (ES) cells. The goals of his participation in the Wellstone Grant are 1) to develop techniques in human ES cells which will allow targeted modification of genes causing muscular dystrophy and 2) to develop protocols for differentiation of normal and gene- targeted cell lines into skeletal muscle and its precursors to determine the steps at which this process fails. An understanding of the molecular mechanisms which fail in differentiating gene-targeted lines could lead to specific therapies. Work which has been completed preparatory to achievement of these goals has been to differentiate murine ES cells into myotubes by a protocol refined in Dr. Baoli Yang's laboratory (The Gene Targeting Core Facility). We are in the process of developing protocols to differentiate human ES cells into myotubes. Also, vectors are being constructed to inactivate the FKRP locus which, when mutated, causes a form of limb-girdle muscular dystrophy. We also plan to specifically modify the Duchenne muscular dystrophy gene by generating specific mutations at the DMD locus which cause this disease in humans.

Recent Publications

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  1. Williamson, R. Prevention of birth defects: folic acid. Biol Res Nurs 3(1):33-8, 2001. [PubMed]
  2. Cragan, J D, Roberts, H E, Edmonds, L D, Khoury, M J, Kirby, R S, Shaw, G M, Velie, E M, Merz, R D, Forrester, M B, Williamson, R A, Krishnamurti, D S, Stevenson, R E, Dean, J H. Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis--United States, 1985-1994. MMWR CDC Surveill Summ 44(4):1-13, 1995. [PubMed]
  3. Williamson, R. Expanded maternal serum alpha fetoprotein screening. Iowa Med 84(9):397-400, 1994. [PubMed]
  4. Williamson, R, Lee, D, Hagaman, J, Maeda, N. Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I. Proc Natl Acad Sci U S A 89(15):7134-8, 1992. [PubMed]
  5. Van Voorhis, B J, Williamson, R A, Gerard, J L, Hammitt, D G, Syrop, C H. Use of oocytes from anonymous, matched, fertile donors for prevention of heritable genetic diseases. J Med Genet 29(6):398-9, 1992. [PubMed]
  6. Williamson, R. Improved screening for fetal chromosome abnormalities. Iowa Med 80(3):125-8, 1990. [PubMed]
  7. Hammitt, D G, Williamson, R A. Screening for cytomegalovirus antibody. Fertil Steril 53(1):185-6, 1990. [PubMed]
  8. Hammitt, D G, Walker, D L, Williamson, R A. Survival and in vitro fertilization potential of sperm following washing and incubation with different protein supplements. Int J Fertil 35(1):46-50, 0. [PubMed]
  9. Hammitt, D G, Hade, D K, Williamson, R A. Survival of human sperm following controlled- and noncontrolled-rate cryopreservation. Andrologia 21(4):311-7, 0. [PubMed]
  10. Hammitt, D G, Bedia, E, Rogers, P R, Syrop, C H, Donovan, J F, Williamson, R A. Comparison of motility stimulants for cryopreserved human semen. Fertil Steril 52(3):495-502, 1989. [PubMed]