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Photo of Thomas Waldschmidt

Thomas Waldschmidt

Professor,  Pathology

Contact Information

Phone: +1 319 335 8223
Email: thomas-waldschmidt@uiowa.edu
Web: Research Laboratory

Education

Post-Doc, Pathology Postdoctoral Fellowship, The University of Iowa
PhD, Immunology, University of Texas Southwestern Medical Center

Appointments

Primary: Pathology

Centers and Program Affiliations

Interdisciplinary Graduate Program in Immunology

Research Interests

B cell immunology, bone marrow transplantation

MeSH Terms from Publications

Mice, B-Lymphocytes, Animals, Mice, Inbred BALB C, Lymphocyte Activation, Mice, Inbred C57BL, B-Lymphocyte Subsets, T-Lymphocytes, Spleen, Flow Cytometry, Receptors, IgE, Germinal Center, Thymus Gland, Receptors, Fc, Ethanol, Antigens, CD, Antigens, CD45, T-Lymphocyte Subsets, Hematopoietic Stem Cells, Cell Differentiation, Female, Immunoglobulin E, CD4-Positive T-Lymphocytes, Mice, Inbred DBA, Receptors, Antigen, B-Cell

Research Summary

B lymphocytes in health and disease: The Waldschmidt laboratory is focused on the studying the function of B cells, one of the key lymphocyte subsets within the adaptive immune system. B cells produce antibodies, an essential weapon used by the body to eliminate extracellular pathogens like bacteria and fungi. Antibodies induced by vaccines are also crucial to protect against infection with viruses such as influenza. Work in the laboratory is focused on three facets of B cell biology: The first is to understand the development and activation of this lymphocyte subset under normal conditions. The second is to fully explore the role of B cell-mediated immunity invoked after influenza infection. The third is to reveal the means by which chronic abuse of alcohol leads to compromised B lymphocyte function and poor antibody responses in alcoholic patients.



Recent Publications


Show publications
  1. Alexander, C, Tygrett, L, Boyden, A, Wolniak, K, Legge, K, Waldschmidt, T. T regulatory cells participate in the control of germinal centre reactions. Immunology 133(4):452-68, 2011. [PubMed]
  2. Case, A, McGill, J, Tygrett, L, Shirasawa, T, Spitz, D, Waldschmidt, T, Legge, K, Domann, F. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med 50(3):448-58, 2011. [PubMed]
  3. Fan, J, Edsen-Moore, M, Turner, L, Cook, R, Legge, K, Waldschmidt, T, Schlueter, A. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res 35(1):47-59, 2011. [PubMed]
  4. Langlois, R, Meyerholz, D, Coleman, R, Cook, R, Waldschmidt, T, Legge, K. Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice. Alcohol Clin Exp Res 34(8):1425-31, 2010. [PubMed]
  5. Lu, P, Hankel, I, Knisz, J, Marquardt, A, Chiang, M, Grosse, J, Constien, R, Meyer, T, Schroeder, A, Zeitlmann, L, Al-Alem, U, Friedman, A, Elliott, E, Meyerholz, D, Waldschmidt, T, Rothman, P, Colgan, J. The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. J Exp Med 207(7):1359-67, 2010. [PubMed]
  6. Takizawa, M, Kim, J S, Tessarollo, L, McNeil, N, Waldschmidt, T J, Casellas, R, Ried, T, Janz, S. Genetic reporter system for oncogenic Igh-Myc translocations in mice. Oncogene 29(28):4113-20, 2010. [PubMed]
  7. McGill, J, Meyerholz, D, Young, B, Coleman, RA, Schlueter, A, Waldschmidt, TJ, Cook, RT, Legge, KL. Fetal exposure to ethanol has long-term effects on influenza viral immunity and disease severity. ALCOHOL 43(8):669-669, DEC 2009.
  8. Chitu, V, Ferguson, P, de Bruijn, R, Schlueter, A, Ochoa, L, Waldschmidt, T, Yeung, Y, Stanley, E. Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice. Blood 114(12):2497-505, 2009. [PubMed]
  9. McGill, J, Meyerholz, D, Edsen-Moore, M, Young, B, Coleman, R, Schlueter, A, Waldschmidt, T, Cook, R, Legge, K. Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections. J Immunol 182(12):7803-8, 2009. [PubMed]
  10. Gurung, P, Young, B, Coleman, R, Wiechert, S, Turner, L, Ray, N, Waldschmidt, T, Legge, K, Cook, R. Chronic ethanol induces inhibition of antigen-specific CD8+ but not CD4+ immunodominant T cell responses following Listeria monocytogenes inoculation. J Leukoc Biol 85(1):34-43, 2009. [PubMed]