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Photo of Michael Welsh

Michael Welsh

Professor,  Internal Medicine

Contact Information

Phone: +1 319 335 7619
Email: michael-welsh@uiowa.edu
Web:

Education

MD, The University of Iowa
Residency, The University of Iowa
Fellowship, University of California, San Francisco
Fellowship, University of Texas

Appointments

Primary: Internal Medicine
Secondary: Physiology & Biophysics
Secondary: Neurosurgery

Centers and Program Affiliations

Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Informatics

Research Interests


MeSH Terms from Publications

Cystic Fibrosis Transmembrane Conductance Regulator, Animals, Cystic Fibrosis, Epithelium, Chlorides, Trachea, Chloride Channels, Sodium Channels, Membrane Proteins, Humans, Cells, Cultured, Membrane Potentials, Cyclic AMP, Mice, Ion Channels, Heat-Shock Proteins, Rats, Dogs, HeLa Cells, Ion Channel Gating, Adenosine Triphosphate, Amiloride, Gene Transfer Techniques, Calcium, Epithelial Sodium Channel

Research Summary

Dr. Welsh's clinical interests include the diagnosis and therapy of lung disease, especially airway diseases. His research focuses in three main areas. First, is a focus on cystic fibrosis with a major emphasis on how the gene product functions, how mutations cause disruptions of function, how the loss of the gene product causes chronic airway infections, and how this knowledge can be used to develop new treatments. Second, his laboratory is working to develop gene therapy for cystic fibrosis and other genetic diseases. Third, he is studying a new family of cation channels involved in sensing mechanical stimuli, noxious stimuli such as ischemia and acidosis, and salt taste.

Recent Publications


Show publications
  1. Demonstration of Phosphoryl Group Transfer Indicates That the ATP-binding Cassette (ABC) Transporter Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Exhibits Adenylate Kinase Activity. J Biol Chem 287(43):36105-10, 2012. [PubMed]
  2. Pancreatic and biliary secretion are both altered in cystic fibrosis pigs. Am J Physiol Gastrointest Liver Physiol 303(8):G961-8, 2012. [PubMed]
  3. Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. Laryngoscope 122(9):1898-905, 2012. [PubMed]
  4. A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A 109(33):13362-7, 2012. [PubMed]
  5. Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways. Am J Pathol 181(2):499-507, 2012. [PubMed]
  6. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature 487(7405):109-13, 2012. [PubMed]
  7. CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia. Am J Physiol Lung Cell Mol Physiol 303(2):L152-60, 2012. [PubMed]
  8. Detecting activity-evoked pH changes in human brain. Proc Natl Acad Sci U S A 109(21):8270-3, 2012. [PubMed]
  9. Safety assessment of nebulized xylitol in beagle dogs. Inhal Toxicol 24(6):365-72, 2012. [PubMed]
  10. Requirements for ion and solute transport, and pH regulation during enamel maturation. J Cell Physiol 227(4):1776-85, 2012. [PubMed]