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Photo of John Widness

John Widness

Professor,  Pediatrics

Contact Information

Phone: +1 319 356 8102
Email: john-widness@uiowa.edu
Web:

Education

BS, Amherst College
MD, Duke University School of Medicine
Internship, Pediatrics, Duke University Hospital
Internship, Internal Medicine, Presbyterian-University Hospital
Residency, Pediatrics, Case Western Reserve University
Fellowship, Neonatology, Brown University

Appointments

Primary: Pediatrics
Secondary: Administration

Centers and Program Affiliations


Research Interests

human physiology, infant, iron, iron metabolism, iron status, medical education, neonate, newborn, obstetrics or gynecology, oxygenation, pediatrics, perinatology, pharmacodynamics, pharmacokinetics, pharmacology, phlebotomy, point-of-care testing, red blood cell transfusion, transfusion medicine, anemia, biotin, erythropoietin, hematology, hemoglobin

MeSH Terms from Publications

Erythropoietin, Sheep, Fetal Blood, Infant, Newborn, Pregnancy, Pregnancy in Diabetics, Humans, Phlebotomy, Female, Erythrocyte Transfusion, Animals, Erythropoiesis, Hematocrit, Hemoglobins, Infant, Premature, Anemia, Iron, Receptors, Erythropoietin, Gestational Age, Infant, Very Low Birth Weight, Birth Weight, Erythrocytes, Recombinant Proteins, Fetus, Anemia, Neonatal

Research Summary

My research involves studies in which red blood cell survival and red cell volume are measured in infants, particularly critically ill infants. My lab is interested in: 1) in identifying the optimal RBC transfusion product to administer to infants; and 2) in understanding mechanisms of RBC survival. Other ongoing pre-clinical and clinical studies involve optimizing erythropoiesis following erythropoietin administration in anemic infants. The focus of these translational studies is on understanding mechanisms of neonatal anemia such that appropriate therapies may be instituted. My principal collaborators include: 1) Donald M. Mock, M.D., Ph.D., University of Arkansas for Medical Sciences; 3) Peter Veng-Pedersen, Ph.D., College of Pharmacy, University of Iowa; and 3) Ronald G. Strauss, M.D., Department of Pathology, University of Iowa. Other Expertise Ad Hoc Reviewer for: Acta Paediatrica , Acta Paediatrica Scandinavia, American Journal of Obstetrics and Gynecology, American Journal of Perinatology, American Journal of Physiology, Archives of Pediatrics & Adolescent Medicine, Diabetes Care, Diabetologia, Early Human Development, European Journal of Biochemistry, Journal of Clinical Investigation, Journal of Pediatric Gastroenterology and Nutrition, Journal of Pediatrics, Journal of Perinatology, Journal of the Society for Gynecologic Investigation, New England Journal of Medicine, Obstetrics and Gynecology, Pediatric Research, Gynecologic and Obstetric Investigation, Archives of Diseases in Childhood.

Recent Publications


Show publications
  1. Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion. Semin Perinatol 36(4):232-43, 2012. [PubMed]
  2. International survey of transfusion practices for extremely premature infants. Semin Perinatol 36(4):244-7, 2012. [PubMed]
  3. Posttransfusion red blood cell (RBC) survival determined using biotin-labeled RBCs has distinct advantages over labeling with (51) Cr. Transfusion 52(7):1596-8, 2012. [PubMed]
  4. Comparison of red blood cell survival in sheep determined using red blood cells labeled with either biotin at multiple densities or [14C]cyanate: validation of a model to study human physiology and disease. Transfusion 52(5):963-73, 2012. [PubMed]
  5. Accelerated removal of antibody-coated red blood cells from the circulation is accurately tracked by a biotin label. Transfusion 52(5):1097-105, 2012. [PubMed]
  6. Multidose optimization simulation of erythropoietin treatment in preterm infants. Pediatr Res 71(4 Pt 1):332-7, 2012. [PubMed]
  7. Acute physiological effects of packed red blood cell transfusion in preterm infants with different degrees of anaemia. Arch Dis Child Fetal Neonatal Ed 96(4):F249-53, 2011. [PubMed]
  8. Receptor-based dosing optimization of erythropoietin in juvenile sheep after phlebotomy. Drug Metab Dispos 39(7):1214-20, 2011. [PubMed]
  9. Differential pharmacokinetic analysis of in vivo erythropoietin receptor interaction with erythropoietin and continuous erythropoietin receptor activator in sheep. Biopharm Drug Dispos 32(5):276-88, 2011. [PubMed]
  10. Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. Arch Pediatr Adolesc Med 165(5):443-50, 2011. [PubMed]