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Photo of Lyse Norian, PhD

Lyse Norian, PhD

Assistant Professor,  Urology

Contact Information

Laboratory
3291 CBRB
Iowa City, IA 52242

Phone: +1 319 335 8406
Email: lyse-norian@uiowa.edu
Web:

Education


Appointments

Primary: Urology

Centers and Program Affiliations


Research Interests


MeSH Terms from Publications

Lymphocyte Activation, T-Lymphocytes, Fas Ligand Protein, Mice, Mice, Inbred BALB C, Mice, Transgenic, Animals, NFATC Transcription Factors, Promoter Regions, Genetic, Antigens, CD95, CD8-Positive T-Lymphocytes, Membrane Glycoproteins, Transcription Factors, Mammary Neoplasms, Experimental, TNF-Related Apoptosis-Inducing Ligand, Jurkat Cells, Nuclear Proteins, CpG Islands, Cell Line, Tumor, DNA-Binding Proteins, Cytotoxicity, Immunologic, Dendritic Cells, Immunotherapy, Adjuvants, Immunologic, Neoplasm Transplantation

Research Summary



Recent Publications


Show publications
  1. Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth. J Immunol 189(3):1311-21, 2012. [PubMed]
  2. Eradication of metastatic renal cell carcinoma after adenovirus-encoded TNF-related apoptosis-inducing ligand (TRAIL)/CpG immunotherapy. PLoS One 7(2):e31085, 2012. [PubMed]
  3. Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Cancer Res 69(7):3086-94, 2009. [PubMed]
  4. TRAIL gene therapy: from preclinical development to clinical application. Curr Gene Ther 9(1):9-19, 2009. [PubMed]
  5. An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med 5(3):e41, 2008. [PubMed]
  6. Rapid maturation of effector T cells in tumors, but not lymphoid organs, during tumor regression. PLoS One 2(9):e821, 2007. [PubMed]
  7. T cell-mediated delay of spontaneous mammary tumor onset: increased efficacy with in vivo versus in vitro activation. J Immunol 174(8):4662-9, 2005. [PubMed]
  8. No intrinsic deficiencies in CD8+ T cell-mediated antitumor immunity with aging. J Immunol 173(2):835-44, 2004. [PubMed]
  9. CD4-directed peptide vaccination augments an antitumor response, but efficacy is limited by the number of CD8+ T cell precursors. J Immunol 172(7):4215-24, 2004. [PubMed]
  10. The regulation of CD95 (Fas) ligand expression in primary T cells: induction of promoter activation in CD95LP-Luc transgenic mice. J Immunol 164(9):4471-80, 2000. [PubMed]