Loki Home

Research Interests

Funding Opportunities

FAQ

UI Login Guest Login

Browse by Investigator Last Name



Browse Research


Photo of Aaron Bossler

Aaron Bossler

Clinical Associate Professor,  Pathology

Contact Information

Phone: +1 319 384 9566
Email: aaron-bossler@uiowa.edu
Web:

Education

BA, Biochemistry, Columbia University
MD, Medical Scientist and Molecular Biology, University of Iowa Carver College of Medicine
PhD, Scientist Training and Molecular Biology, University of Iowa Carver College of Medicine
Residency, Clinical Pathology, University of Iowa Hospitals and Clinics
Fellowship, Molecular Genetic Pathology, Hospital of the University of Pennsylvania

Appointments

Primary: Pathology

Centers and Program Affiliations


Research Interests

infectious disease, molecular pathology, virology

MeSH Terms from Publications

Protein Tyrosine Phosphatase, Non-Receptor Type 13, Humans, Human papillomavirus 16, Oncogene Proteins, Viral, Palatine Tonsil, Papillomaviridae, Keratinocytes, Lymphangiogenesis, Activin Receptors, Type II, Virus Replication, Blotting, Southern, Exophiala, Genomic Islands, Telangiectasia, Hereditary Hemorrhagic, Interferon Regulatory Factor-2, Repressor Proteins, Proto-Oncogene Proteins c-bcl-6, Foreskin, Human papillomavirus 18, Carcinoma, Squamous Cell, Human papillomavirus 11, Interferon Regulatory Factor-1, Female, Genes, rRNA, Muscular Dystrophy, Facioscapulohumeral

Research Summary

Dr. Bossler's clinical service duties include molecular pathology with a special interest in molecular infectious disease testing. His research interest is in the development and validation of rapid and cost effective molecular assays for the detection and quantification of viral organisms, bacterial antibiotic resistance surveillance, and detection of difficult-to-grow organisms amenable to molecular detection using real-time PCR or sequencing technologies.

Recent Publications


Show publications
  1. Bossler, A, Gunsolly, C, Pyne, M, Rendo, A, Rachel, J, Mills, R, Miller, M, Sipley, J, Hillyard, D, Jenkins, S, Essmyer, C, Young, S, Lewinski, M, Rennert, H. Performance of the COBAS® AmpliPrep/COBAS TaqMan® automated system for hepatitis C virus (HCV) quantification in a multi-center comparison. J Clin Virol 50(2):100-3, 2011. [PubMed]
  2. Shenoy, A, Markowitz, J, Bonnemann, C, Krishnamoorthy, K, Bossler, A, Tseng, B. Muscle-Eye-Brain disease. J Clin Neuromuscul Dis 11(3):124-6, 2010. [PubMed]
  3. Tsumagari, K, Chen, D, Hackman, J R, Bossler, A D, Ehrlich, M. FSH dystrophy and a subtelomeric 4q haplotype: a new assay and associations with disease. J Med Genet 47(11):745-51, 2010. [PubMed]
  4. Lace, M, Anson, J, Klingelhutz, A, Lee, J, Bossler, A, Haugen, T, Turek, L. Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs. J Virol 83(22):11784-94, 2009. [PubMed]
  5. Lace, M, Anson, J, Klingelhutz, A, Harada, H, Taniguchi, T, Bossler, A, Haugen, T, Turek, L. Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1. Carcinogenesis 30(8):1336-44, 2009. [PubMed]
  6. Hoover, A C, Strand, G L, Nowicki, P N, Anderson, M E, Vermeer, P D, Klingelhutz, A J, Bossler, A D, Pottala, J V, Hendriks, W, Lee, J H. Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway. Oncogene 28(45):3960-70, 2009. [PubMed]
  7. Spanos, W, Hoover, A, Harris, G, Wu, S, Strand, G, Anderson, M, Klingelhutz, A, Hendriks, W, Bossler, A, Lee, J. The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. J Virol 82(5):2493-500, 2008. [PubMed]
  8. Spanos, W, Geiger, J, Anderson, M, Harris, G, Bossler, A, Smith, R, Klingelhutz, A, Lee, J. Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells. Head Neck 30(2):139-47, 2008. [PubMed]
  9. Wang, H, Bossler, A, Schaffer, A, Tomczak, E, DiPatri, D, Frank, D, Nowell, P, Bagg, A. A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma. Cancer Genet Cytogenet 172(1):45-53, 2007. [PubMed]
  10. Link, B, Ballas, Z, Weisdorf, D, Wooldridge, J, Bossler, A, Shannon, M, Rasmussen, W, Krieg, A, Weiner, G. Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma. J Immunother 29(5):558-68, 0. [PubMed]